Although no group has claimed responsibility for Bhutto's killing, Western leaders immediately pointed to the Islamic extremist groups operating with increasing intensity in Pakistan, including those with links to al-Qaeda.
Yelling "Musharraf is a dog," they blamed him for Bhutto's death.
Bush, whose administration played a key role in arranging Bhutto's return to the country Oct. 18, spoke by telephone with Musharraf hours after her death.
In the narrow corridor outside the operating room, supporters cried out: "Long live Bhutto!" and "Musharraf is a murderer!"
"This is the height of brutality. They have hanged her father. They have killed her brothers. The government has killed all the good people of Pakistan," said Sarfraz Khan. "Please pray for us. Pray for our poor country."